A database system for functional genomics and systems biology
DOME is a system for managing, and analysing genome-wide profiling data, now known as systems biology . It is dedicated to experiments where samples are processed with transcriptomics, proteomics, and metabolomics
technologies. DOME is for integrated analyses spanning those three data types.
DOME is a laboratory database intended to manage the data generated in one or several projects. The system has not been designed to become a public repository, though the code could be used for that purpose if wanted. DOME should be installed in each laboratory that desires to use this system. The DOME databases hosted in our website are only for those projects in which we are active participants (Medicago truncatula
and grape functional genomics, and yeast systems biology
DOME is a client-server application and is fully accessible from a web browser (i.e. DOME users do not have to install new software). The web front-end guides the user to make complex queries to select data by diverse criteria. Query results are then available to be displayed in table format, downloaded in data files, visualized within pathway diagrams, or processed with multivariate analysis algorithms, such as k
-means clustering, non-negative matrix factorization and PCA.
DOME is open source, and is freely available to download. Unfortunately we have no funded resources to maintain this software and there is no support beyond these web pages.
The DOME team: Bharat Mehrotra, Xing Jing Li, Aejaaz Kamal, Saroj Mohapatra, and Pedro Mendes. Stefan Hoops and Olga Brazhnik also participated in earlier development of the project.
This material is based upon work supported by the National Science Foundation under Grant No. 0109732. Any opinions findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.