alf@vt.edu brazhnik@vt.edu mendes@vt.edu
[Abstract] [Model, equations and parameter values] [Perturbation data] [Analysis of gene network]
Parameter | Explanation | Value | |
V_{LUG} | overall production rate of mRNA LUG | 1 mMs^{-1} | |
k_{LUG} | degradation rate constant of mRNA LUG | 1 s^{-1} | |
V_{AG} | overall production rate of mRNA AG | 100 mMs^{-1} | |
K_{I1LUG} | inhibition constant for LUG on expression of AG | 1 mM | |
K_{I1AP1} | inhibition constant for AP1 on expression of AG | 10 mM | |
K_{I1TFL1} | inhibition constant for TFL1 on expression of AG | 100 mM | |
K_{A1LFY} | activation constant for LFY on expression of AG | 10 mM | |
k_{AG} | degradation rate constant of mRNA AG | 1 s^{-1} | |
V_{AP1} | overall production rate of mRNA AP1 | 10 mMs^{-1} | |
K_{I1AG} | inhibition constant for LUG on expression of AP1 | 10 mM | |
K_{I1EMF1} | inhibition constant for API on expression of AP1 | 10 mM | |
K_{A2LFY} | activation constant for LFY on expression of AP1 | 10 mM | |
k_{AP1} | degradation rate constant of mRNA AP1 | 1 s^{-1} | |
V_{EMF1} | overall production rate of mRNA EMF1 | 1 mMs^{-1} | |
k_{EMF1} | degradation rate constant of mRNA EMF1 | 1 s^{-1} | |
V_{TFL1} | overall production rate of mRNA TFL1 | 100 mM^{-1} | |
K_{I1LFY} | inhibition constant for LFY on expression of TFL1 | 10 mM | |
K_{A1EMF1} | activation constant for EMF1 on expression of TFL1 | 0.1 mM | |
k_{TFL1} | degradation rate constant of mRNA TFL1 | 1 s^{-1} | |
V_{LFY} | overall production rate of mRNA LFY | 100 mMs^{-1} | |
K_{I2EMF1} | inhibition constant for EMF1 on expression of LFY | 10 mM | |
K_{I2TFL1} | inhibition constant for TFL1 on expression of LFY | 100 mM | |
K_{A1AP1} | activation constant for AP1 on expression of LFY | 10 mM | |
k_{LFY} | degradation rate constant of mRNA LFY | 1 s^{-1} | |
V_{SUP} | overall production rate of mRNA SUP | 0.1 mMs^{-1} | |
k_{SUP} | degradation rate constant of mRNA SUP | 1 s^{-1} | |
V_{AP3} | overall production rate of mRNA AP3 | 10 mMs^{-1} | |
K_{I1SUP} | inhibition constant for SUP on expression of AP3 | 1 mM | |
K_{A3LFY} | activation constant for LFY on expression of AP3 | 10 mM | |
K_{A1AP3} | auto activation constant for AP3 on expression of AP3 | 1 mM | |
K_{A1PI} | activation constant for PI on expression of AP3 | 1 mM | |
K_{A1UFO} | activation constant for UFO on expression of AP3 | 1 mM | |
k_{AP3} | degradation rate constant of mRNA AP3 | 1 s^{-1} | |
V_{PI} | overall production rate of mRNA PI | 10 mMs^{-1} | |
K_{I2SUP} | inhibition constant for SUP on expression of PI | 1 mM | |
K_{A4LFY} | activation constant for LFY on expression of PI | 10 mM | |
K_{A2AP3} | activation constant for AP3 on expression of PI | 1 mM | |
K_{A2PI} | auto activation constant for PI on expression of PI | 1 mM | |
K_{A2UFO} | activation constant for UFO on expression of PI | 1 mM | |
k_{PI} | degradation rate constant of mRNA PI | 1 s^{-1} | |
V_{UFO} | overall production rate of mRNA UFO | 10 mMs^{-1} | |
k_{UFO} | degradation rate constant of mRNA UFO | 1 s^{-1} |
Steady state concentrations | LUG | AG | AP1 | EMF1 | TFL1 | LFY | SUP | AP3 | PI | UFO |
Steady state 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Perturbation in rate V_{LUG} | 1.1 | 0.946451 | 1.04343 | 1 | 0.997919 | 1.002352 | 1 | 1.000395 | 1.000395 | 1 |
Perturbation in rate V_{AG} | 1 | 1.112846 | 0.919299 | 1 | 1.004388 | 0.995072 | 1 | 0.999167 | 0.999167 | 1 |
Perturbation in rate V_{AP1} | 1 | 0.983643 | 1.114812 | 1 | 0.99485 | 1.005839 | 1 | 1.000978 | 1.000978 | 1 |
Perturbation in rate V_{EMF1} | 1 | 0.998402 | 0.990945 | 1.1 | 1.018428 | 0.988819 | 1 | 0.998099 | 0.998099 | 1 |
Perturbation in rate V_{TFL1} | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Perturbation in rate V_{LFY} | 1 | 0.987437 | 1.00868 | 1 | 1.109538 | 0.990304 | 1 | 0.998353 | 0.998353 | 1 |
Perturbation in rate V_{SUP} | 1 | 1 | 1 | 1 | 1 | 1 | 1.1 | 0.986623 | 0.986623 | 1 |
Perturbation in rate V_{AP3} | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1.124096 | 1.021906 | 1 |
Perturbation in rate V_{PI} | 1 | 1 | 1 | 1 | 1 | 1 | 1.124096 | 1.021906 | 1 | 1 |
Perturbation in rate V_{UFO} | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1.012361 | 1.012361 | 1.1 |