New paper on network effect of kinetic isotope effects

Posted on: Oct 23, 2015

A new paper with Pierre Millard and Jean-Charles Portais studies the effect of kinetic isotope effects at the systems level. It has been known that isotopes have marked effect on the kinetics of many enzymes. Thus, it seemed that they would also have a strong effect on metabolic pathways or the entire metabolic system. However this does not seem to be the case... This means that there is still high value in 13C-labelled flux measurements.

Millard P, Portais J-C, Mendes P (2015) Impact of kinetic isotope effects in isotopic studies of metabolic systems. BMC Systems Biology 9:64.