Pedro Mendes is a Professor of Computational Systems Biology at the School of Computer Science, University of Manchester. He is also a principal investigator at the Virginia Bioinformatics Institute.

Major projects that we participate in are the COPASI simulation software, the Manchester Centre for Integrative Systems Biology, the UNICELLSYS FP7 project. We have many other collaborators.

We follow an approach that is known as Systems Biology, where biological phenomena are seen as resulting from the interactions of its constituents. Our focus is mainly on the biochemical level, where the constituents are macromolecules and metabolites, and the interactions are reactions, diffusion and transport. Interpreting these phenomena requires the use of quantitative methods and therefore computation. We work on many aspects of Computational Systems Biology:

• Development of modelling and simulation software
• (nonlinear) dynamics of biochemical models
• Parameter estimation and sensitivity analysis
• Reverse-engineering biological networks (top-down modelling)
• Standards for systems biology software
• Biological data mining using machine learning and statistical methods
• Data integration and data fusion for biology

We are also very involved with the analysis and modelling of biological phenomena around oxidative stress:

• the yeast regulatory response to oxidative stress
• the network of iron absorption, metabolism and signalling
• the pentose phosphate pathway
• specific redox responses of malignant cells.

Students interested in working with Pedro Mendes, should consult this page.